Grey's Anatomy will air its winter finale episode this Thursday, Nov. 19.

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The episode is called "Things We Lost in the Fire," and in it Dr. Jo Wilson (Camilla Luddington) will confront Dr. Alex Karev (Justin Chambers) about his super close friendship with Dr. Meredith Grey (Ellen Pompeo).

Alex always seems to be there for Meredith, unlike Jo, despite the fact that she is his girlfriend. The problem is brewing now that Jo clearly cannot stand avoiding it anymore.

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Watch ABC's sneak peek below, in which Jo confronts Alex - and things get awkward.

"We are never eating in that cafeteria again," Alex tells Jo as she works on a patient.

"I'm a little busy right now," she replies to him, adding, "Do you need something?" in a bit of a standoffish way.

Alex mentions he's on a break and Jo unleashes everything she's kept bottled up.

"You know when I had a minute? This morning when you and Meredith were whispering in the hallway," Jo says to him.

He tries to apologize, but she isn't done with her rant.

"And she yelled 'Get away!' in my face like I was a stray dog," Jo adds, which makes Alex laugh, which only annoys Jo more.

"God, you always defend her even when she's being a complete b---- to me," she barks at Alex.

Alex then tells her not to call Meredith that and their argument escalates.

"She's always your priority!" Jo shouts, leading him to defend Meredith even more.

"That's not true. She's been through a lot!" he shouts in return, explaining, "Her husband died."

From there Alex then explains that Meredith is allowed to depend on him.

"It means I'm going to be there for her when she needs me cause she's the only one I can count on," he says, only angering Jo more since she is his girlfriend and he should be able to "count on" her too.

Their argument ends with tears welling up in Jo's eyes as she tells Ales to leave so she can "focus" on her patient.

Jo and Alex aren't the only ones with relationship problems; Dr. Maggie Pierce (Kelly McCreary) and Dr. Andrew DeLuca (Giacomo Gianniotti) will have issues keeping things professional.

Relationship problems aside, the Grey Sloan Memorial Hospital staff will be slammed with a bunch of injured firefighters as noted in this press release.

Grey's Anatomy airs on ABC on Thursdays at 8 p.m. ET.

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Greys anatomy, ABC, Television