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LOS ANGELES, CALIFORNIA - DECEMBER 08: Terrence Howard announces lawsuit against CAA over "Empire" salary at The Cochran Firm on December 08, 2023 in Los Angeles, California. (Photo by Kevin Winter/Getty Images)

Neil deGrasse Tyson has responded to Terrence Howard's scientific research and his attempt at re-evaluating mathematics and physics.

During an episode of 'The Joe Rogan Experience,' the 'Hustle & Flow' actor claimed Tyson "attacked" his 36-page treatise, and "redlined everything." The astrophysicist cites the actor's current mindset as a "valley of false confidence."

"Let me make it clear — I'm delighted when I see people with active minds trying to tackle the great unknowns in the universe," Tyson, 65, said on a recent episode of his 'Startalk' podcast regarding the work Howard sent to him eight years ago.

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"It's possible to know enough about that subject to think you're right, but not enough about that subject to know that you're wrong. There's this sort of valley in there — a valley of false confidence," the astrophysicist said, citing the Dunning-Kruger Effect.

Regarding Howard's bombshell manifesto, Tyson responded that the claims written were "a clear indication of a restless, active mind." The scientist also went on to state that Howards study contained many "assumptions and statements that are under-informed, misinformed, or simply false."

The "peer review" and "critical analysis" Tyson gave ultimately states the misinformation listed compromises and nullifies many of the subsequent conclusions Howard has drawn within the study.

Tyson responded to 'The Best Man's' star's claims that he "trashed" researchers that Howard listed in the study, but claims he was just "stating the fact."

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NEW YORK, NEW YORK - MARCH 17: Neil deGrasse Tyson speaks during a Q (Photo by John Lamparski/Getty Images)

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"I don't think of that as trashing, I think of that as being honest. I could have softened it but I don't think that's what people who care about you should do. People who care will be honest with you about ideas and thoughts," Tyson retorted. "There's an old saying...I first heard it from Michael Dell of Dell Technologies...'If one day you find yourself the smartest person in the room — change rooms.' "

In a 2015 interview with 'Rolling Stone,' Howard, 55, claimed that he had formed his own language of logic, which he kept a secret till he patented it. Using said logic, the award-winning actor claimed he could prove that 1 x 1 = 2.

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Neil deGrasse Tyson, Terrence Howard