It looks like Jennifer Aniston and Courteney Cox might not be the biggest of "Friends" after all. Rumor has it that Cox is furious with her best friend Aniston for apparently shading her in a new interview in which she slams women who get plastic surgery done on their faces.

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Specifically, Cox thinks that Aniston made personal jabs at her when she said in an interview that she would never consider getting botox or "messing with her face" because her fiancé Justin Theroux "would put a gun to her head."

Aniston, who opened up about her beauty regime to Yahoo last week, says that Theroux would take to extreme measures to make sure she would never "mess with her face."

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"There is this pressure in Hollywood to be ageless," Aniston told the site. "I think what I have been witness to, is seeing women trying to stay ageless with what they are doing to themselves. I am grateful to learn from their mistakes, because I am not injecting s--- into my face."

A source told Star Magazine's print edition on Friday, "Courtney is upset that she made the remarks publicly, but this certainly isn't a shock to her. It's happened many times before."

And while Aniston might have made the comment in general, the source adds that Cox is still taking it very personal as she believes those jabs were made with her in mind.

The source added, "She can deny it, but who else could she possibly have meant?"

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