He was known as the brilliant man who inspired A Beautiful Mind and now he is gone because of a tragic car crash.

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On Sunday, MSN reported that the Princeton University mathematician John Nash who has struggled with mental health issues and inspired the Oscar-winning film has died at age 86.

Nash and his 82-year-old wife, Alicia Nash, died when the taxi they were riding in crashed into a guardrail. The two were reportedly not wearing seat belts and were ejected from the car when the driver attempted to pass another driver and was going so fast that he lost control.

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Nash was known for his work in game theory, differential geometry and other mathematical research that influenced economics, artificial intelligence, computer technology and other industries.

He shared the 1994 Nobel Price for his work in economics along with Reinhard Selten and John Harsanyi, according to the report.

Nash's biography influence the 2001 film, A Beautiful Mind, that documented his academic accomplishments and his struggle with schizophrenia that nearly cost him his family and career.

The film earned an Academy Award for Best Picture. Russell Crowe was nominated for an Oscar for his portrayal of Nash in the movie.

When news broke of the accident, Crowe immediately took to Twitter to express his remorse.

"Stunned...my heart goes out to John & Alicia & family. An amazing partnership. Beautiful minds, beautiful hearts," he said.