We first saw them together on-screen sitting in a therapist's office in 2005's 'Mr. & Mrs. Smith', where they played a very unhappy couple who were literally trying to kill each other.

Now, Pitt, 51, and Jolie, 40, have another movie together - 'By The Sea', a film written, directed and produced by Jolie. In the new film, the 'Brangelina' stars as a couple whose marriage is disintegrating, though Jolie assured that the film isn't based on their relationship. The plot of the film couldn't be further from the truth about the couple in real life.

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"I'm counting on the audience to know that if it was close to us at all, we could never make this film, it's because we're actually very, very stable and these aren't our issues." the star revealed in an interview with Tom Brokaw for TODAY.

The film was inspired by Jolie's grief after the death of her mother, actress Marcheline Bertrand, who was diagnosed with ovarian cancer in 1999 and died in 2007 at the age of 56.

"We can't say what the whole film is about, but a lot of the film was when I went to visit my mom in the hospital, when she found out she had cancer the first time," the actress said. "She was gonna have her ovaries removed, (and) she was very upset, feeling like...they're taking out her parts that were female, and there was a woman down the hall who was wailing. I later found out it was a young woman who had not had children yet, and that put everything into perspective."

They also talked about Jolie's recent health struggles and how she valued Pitt's support when she underwent a preventative double mastectomy in 2014 and then had her ovaries and fallopian tube removed earlier this year.

"There was no vanity to my wife's approach," Pitt said. "It was mature...it was just another one of those things in life that makes you tighter. She was doing it for her kids, she was doing it for her family."

Jolie echoed his sentiments.

"He made it very, very clear to me that what he loved, and what was a woman to him was someone who was smart and capable and cared about her family," the 'Maleficent' star said.

"I knew, through the surgeries, that he was on my side and that this wasn't something where I was gonna feel less of a woman because my husband wasn't gonna let that happen," she added. "To face these issues together and speak about them an dtalj about what it is to be human, I think can be a beautiful thing."

Catch 'By The sea' in theaters near you on Nov. 13.

Tags
Angelina Jolie, Brad Pitt, Brangelina, Celebrity couple, Family, Health