The first Presidential debate will air live from the University of Denver in Denver, Colorado at 9 p.m. EST Wednesday on the major networks and news channels: ABC, CBS, FOX, NBC and on cable news channels C-SPAN, CNN, Fox News, and MSNBC.

On the web, YouTube, Ustream and 2012presidentialelectionsnews.com will offer live streaming of the event.

YouTube will stream all three presidential debates and vice presidential debates on its special section called "Election Hub."

More than 50 million viewers and some estimate that could be up to 80 million those who are expected to tune in to watch the Presidential debate from their homes.

All eyes will be on President Barack Obama and Mitt Romney as they discuss domestic policy with moderator Jim Lehrer over a 90-minute period.

One of the key points for Romney would be to explain his infamous remarks at a fund-raising event with millionaire donors. Romney said about 47% of Americans "are dependent upon government; who believe that they are victims; who believe the government has a responsibility to care for them; who believe that they are entitled to health care, to food, to housing - to you-name-it."

"The governor is prepared, obviously, to respond to that," senior aide Ed Gillespie told the New York Daily News Tuesday.

In the other hand, Obama will try to explain Americans why the economy will improve under his Government if he is elected for a second term, after his first term failed to do so.

The debate's format will be composed of six 15-minute time segments each of which will focus on the following topics: Economy I,II,III, Health Care, The Role of Government and Governing.

The next two debates will be on October 16 and October 22.